Investigate of Haemostatic and Fibrinolytic System Parameters among Sickle Cell Anaemia Patients in the Khartoum State

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Elteleb G. Elnaim
Samar Ibrahim
Duaa Ahmed
Rayan Aldaw
Nagwa Salih
Muna Musa
Esraa Yosuif
Samah A. Ali
Hassan Abdallah Abdalrahim Hamed
Enaam H. Mohammed
Naser Eldin Bilal

Abstract

Introduction: A sickle cell anaemia one of a haemoglobinopathy, which constituted as a model for genetically inherited disorders, the course of the disease involves may crises, the investigation of hemostatic components as fibrinogen and fibrinolysis as D-dimer, reflect the overall hemostatic status in the sickle cell anaemia patients. Aim: To investigates hemostatic and fibrinolytic system parameters among sickle cell anaemia patients in the Khartoum state. Methods: The study was conducted in Khartoum state, in JafarIbn Auf Reference Hospital for children as descriptive case-control, a laboratory-based study from 2017-18, specimens were collected randomly of the study population with irrespective to age and gender, blood draw in tri-sodium citrate container, the ethical and consent were obtained. The fibrinogen level was estimated by CA51 semi-automated coagulation analyzer optically based, and the D-dimer were assayed by MISPA-i2, a nephelometric based, the results for each parameter were recorded and using statistical package for the social sciences (SPSS) software for analysis by independent T-test and the statistical significance > 0.05. Results: A hundred participants fifty as study group (HbSS) sickle cell anemic Sudanese child clinically and laboratory-confirmed and fifty healthy as the control group, in comparing a mean of fibrinogen show statistically insignificant (P value 0.645) study group 291.1 ± 107.8 mg/dL and control group 283.4 ± 49.1 mg/dL, but there was a significant difference in comparing a mean of D-dimer in study group 0.56 ± 0.33 μg/mL and control group 0.33 ± 0.14 the P. value 0.00015. Conclusion: The level of D-dimer may be used as a hypercoagulability biomarker in comparison to the level of fibrinogen level for sickle cell anaemia Sudanese child.

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Elnaim E, Ibrahim S, Ahmed D, Aldaw R, Salih N, Musa M, Yosuif E, Ali S, Hamed H, Mohammed E, Bilal N. Investigate of Haemostatic and Fibrinolytic System Parameters among Sickle Cell Anaemia Patients in the Khartoum State. IJPBR [Internet]. 25Jun.2020 [cited 1Oct.2020];8(02):01-5. Available from: https://www.ijpbr.in/index.php/IJPBR/article/view/738
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